06 - Jagdpanzer IV L/48 Vol. 6 Photosniper Series by Krzysztof & Parada, George Mucha

By Krzysztof & Parada, George Mucha

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Gene Loci Involved in Production of Serum Interferon in Inbred Mouse Strains Viral inducer Number of loci involved Designation Newcastle disease virus Mouse mammary tumor virus Sendai virus 1 1 2 If-1 If-2 If-3 and If-4 32 MECHANISMS OF INTERFERON PRODUCTION genetics of interferon production may answer many questions about gene organization and control in animals. It is certainly possible that many more forms of interferons exist than we are presently aware of and that each form has a distinct gene.

They are somewhat atypical in that interferon production is a bit late with respect to virus replication; interferon production induced by polylC begins within 2 hr of addition of the inducer. The production of interferons (Fig. 5) has an induction phase of several hours in which the inducer binding, uptake, and processing must take place. The interferon gene then must be derepressed because an interferon is usually an induced protein (there are, however, unusual cell types where it is constitutive).

A number of low-molecular-weight interferon inducers have been reported. Tilorone (bisdiethylaminoethyl fluorenone) induces interferon synthesis in mice, but alas, not in humans. The dyes acridine and quinacrine also induce interferon in animals. Finally, to complete the list of active small molecules, propanediamine, a quinoline compound (BL-20803), a furan (MA-56), the radioprotective mercaptoalkylamine AET, and a substituted pyrimidine all induce interferon in animals and in some cases in tissue cultures.

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