Acute Exposure Guideline Levels for Selected Airborne by National Research Council, Division on Earth and Life

By National Research Council, Division on Earth and Life Studies, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels

Within the Bhopal catastrophe of 1984, nearly 2,000 citizens dwelling close to a chemical plant have been killed and 20,000 extra suffered irreversible harm to their eyes and lungs following the unintended liberate of methyl isocyanate. This tragedy served to concentration overseas recognition at the want for governments to spot damaging components and help neighborhood groups in making plans the best way to take care of emergency exposures. due to the fact 1986, the U.S. Environmental safety company has been tasked with choosing tremendous damaging components and, in cooperation with the Federal Emergency administration service provider and the dept of Transportation, help neighborhood emergency reaction planners. The nationwide Advisory Committee on Acute publicity guide degrees for dangerous elements used to be demonstrated in 1995 to increase acute publicity instruction degrees (AEGLs) for top precedence poisonous chemical compounds which may be published into the air from injuries at chemical crops, garage websites, or in the course of transportation. This e-book studies toxicity files on 5 chemical compounds - chlorine, hydrogen chloride, hydrogen fluoride, toluene, and uranium hexafluoride - for his or her medical validity, comprehensives, inner consistency, and conformance to the 1993 instructions record.

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The exposure was performed under static conditions, and the measurement method was not described. du Pont de Nemours 1982a). No deaths occurred at the lowest concentration. Signs at 359 ppm included cyanosis, tremors, lacrimation, salivation, semi-prostration, an initial bodyweight loss followed by normal gain, and a reddish-brown perineal area. Groups of five adult male Sprague-Dawley rats (200–250 g) were exposed to reagent grade aniline at concentrations of 0, 10, 30, 50, 100, or 150 ppm for 8 h/d for 5 d or 12 h/d for 4 d (Kim and Carlson 1986).

5 100 22 23 41 46 150 aValues shown represent estimates from graphic representations of the data. Source: Kim and Carlson 1986. About this PDF file: This new digital representation of the original work has been recomposed from XML files created from the original paper book, not from the original typesetting files. Page breaks are true to the original; line lengths, word breaks, heading styles, and other typesetting-specific formatting, however, cannot be retained, and some typographic errors may have been accidentally inserted.

On d 20, fetuses from dams in group 1 exposed at 100 mg/kg/d exhibited increased relative liver weights and enhanced hematopoietic activity, but there was no evidence of embryolethality or teratogenicity. Effects in pups observed from post-natal d 0 to 60 (group 2) included transient decreased body weights (dose-related; significant only in the 100-mg/kg/d group), elevated relative liver weights (not dose related), and elevated relative spleen weights (dose-related trend, only on post-natal d 25).

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