Advances in Prostaglandin and Leukotriene Research: Basic by Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson

By Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson (auth.), Bengt Samuelsson, R. Paoletti, Giancarlo C. Folco, E. Granström, S. Nicosia (eds.)

This quantity is the court cases of the eleventh foreign convention on Advances in Prostaglandin and Leukotriene study: uncomplicated technological know-how and New scientific purposes, held in Florence, Italy, on June 4-8, 2000, which maintains the culture of protecting either easy and scientific elements of prostaglandin and leukotriene examine.

At this assembly specific emphasis used to be given to the capability software of the radical COX-2 inhibitors, the genetics of bronchial asthma when it comes to the construction of leukotrienes, and novel mobile networks for the creation of leukotrienes and lipoxins.

Traditionally, as has been performed in previous conferences of this sequence, a large amount of new fabric was once awarded and mentioned this yr, with specific recognition given to the latest scientific data.

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The L TC4S protein and activity continued to increase as the hybrid eosinophils lost basophilic granules to become mature eosinophils [2]. Thus, the data revealed a direct correlation between the developmental stages of eosinophils and the level of LTC4 S expression. Mitogenic and Inflammatory Stimuli Induce LTC 4S Expression LTC4S expression can be induced in many leukemia celllines, with levels ranging from none (HL-60 cells) to minimal (U937 cells) to high (HEL and THP-l cells), without mitogenic stimulation.

Cells were cultured under the indicated culture conditions. Then, 5-LO activity of intact cells and cell homogenates was determined in the absence of exogenously added thiols. However, when 5-LO activity was determined in the corresponding cell homogenates in the absence of exogenously added thiols, there was a similar 5-LO activity under all cell culture conditions in HL-60 cells and in BL41-E95A cells, respectively. In contrast, in cell homogenates ofMono Mac 6 cells, 5-LO activity was low when the cells were cultured in the presence of selenium whereas high 5-LO activity was only observed under selenium free conditions.

3. 4. Drazen JM, Israel E, O'Byme PM. Treatment of asthma with drugs modifying the leukotriene pathway. N Engl J Med 1999;340:197-206. Boyce JA, Lam BK, Penrose JF, et al. Expression of LTC 4 synthase during the development ofeosinophils in vitro from cord blood progenitors. Blood 1996;88:4338-47. Scoggan KA, Nicholson DW, Ford-Hutchinson AW. Regulation of leukotrienebiosynthetic enzymes during differentiation of myelocytic HL-60 cells to eosinophilic or neutrophilic cells. Eur J Biochem 1996;239:572-78.

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